Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic ratsviaIGF-1 signaling pathway
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چکیده
منابع مشابه
Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice
BACKGROUND & AIMS Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 admini...
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Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...
متن کاملEffects of ethyl acetate extract of Salsola collina on brain-gut peptides and interstitial cells of gastric Cajal in rats with diabetic gastroparesis
Objective(s): Effects of ethyl acetate extract of Salsola collina (EES) on brain-gut peptides and interstitial cells of gastric Cajal in rats with diabetic gastroparesis were explored. Materials and Methods: Rats were divided into six groups: normal control group (NC), diabetic gastroparesis model group (DGP), low, medium, and high dose ...
متن کاملThe pacemaker activity of interstitial cells of Cajal and gastric electrical activity.
Interstitial cells of Cajal (ICC) are the pacemaker cells in the gut. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal muscles. The electrical slow wave activity determines the characteristic frequency of phasic contractions of the stomach, intestine and colon. Slow waves also determine the direction and velocity of pro...
متن کاملSynchronized Dual Pulse Gastric Electrical Stimulation Induces Activation of Enteric Glial Cells in Rats with Diabetic Gastroparesis
Objective. The aims of this study were to investigate the effects of synchronized dual pulse gastric electrical stimulation (SGES) on gastric motility in different periods for diabetic rats and try to explore the possible mechanisms of the effects. Methods. Forty-six rats were used in the study. Gastric slow waves were recorded at baseline, 7-14-day diabetes and 56-63-day diabetes before and af...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2016
ISSN: 1007-9327
DOI: 10.3748/wjg.v22.i23.5353